一 | 在发表于《Oncotarget》杂志的一项研究中，约翰斯·霍普金斯大学医学院神经外科和肿瘤学教授Gregory Riggins博士和他的团队使用两种不同的小鼠模型来确定抗寄生虫药物甲苯达唑可以减缓或阻止早期和晚期胰腺癌的生长和扩散。 E-commerce giant Amazon is under investigation by the UK's competition watchdog over claims it favors its own warehouses over third-party sellers.,The Competition and Markets Authority (CMA) will look into whether customers are getting a "worse deal" due to the online retailer giving an unfair advantage to its retail arm or sellers who use its services in the Amazon UK Marketplace.,In particular, the probe will examine how Amazon uses third-party retailers' data and its criteria for access to the "Amazon Prime" service, which includes free deliveries. It will also look at how Amazon decides which company's product has the privilege of featuring in the instant "Buy Box" on the website's home page.,"Millions of people across the UK rely on Amazon's services for fast delivery of all types of products at the click of a button," said CMA general counsel Sarah Cardell. "This is an important area so it's right that we carefully investigate whether Amazon is using third-party data to give an unfair boost to its own retail business and whether it favours sellers who use its logistics and delivery services - both of which could weaken competition.",Bezos’ $500M Megayacht Stranded After Dutch Firm Abandons Bid to Dismantle Rotterdam Bridge3 July, 04:03 GMT,"Thousands of UK businesses use Amazon to sell their products and it is important they are able to operate in a competitive market," Cardell added. "Any loss of competition is a loss to consumers and could lead to them paying more for products, being offered lower quality items or having less choice.",Billionaire Amazon founder Jeff Bezos also owns the liberal US Washington Post newspaper. The company has been criticized for its treatment of warehouse staff and its resistance to recognizing trade unions.。“我们认为甲苯咪唑可能在所有阶段都有作用，”Riggins说。“它对早期发现的胰腺癌特别有效。”Riggins和他的团队将甲苯咪唑注射到经过基因工程改造后患上胰腺癌的小鼠身上。该团队测量了炎症和组织的变化，以及每个肿瘤的阶段、分级和转移状态。
二 | 甲苯咪唑最初是通过切断寄生虫的营养供应来对抗蛔虫、钩虫和其他寄生虫感染，它能抑制微管蛋白的形成。
三 | Riggins解释说，微管蛋白既是细胞内部的微观“骨架”，也是“运输的高速公路”。该药物进入寄生虫的肠道并破坏微管蛋白，使寄生虫饿死。该研究表明，甲苯咪唑可能在胰腺癌中发挥类似的作用，通过塌陷癌细胞的结构，同时还有其他机制，如减少炎症。Riggins说，他希望通过人体临床试验继续他的团队的研究：“我们主张将甲苯咪唑作为一种疗法用于那些在转移前被诊断出来的人，看看我们是否可以减缓或预防胰腺癌，”Riggins说。“对于那些更晚期的癌症患者，它可能是某些手术的替代方案。甲苯咪唑作为初始治疗后的一种疗法可能有实用价值，以防止15%至20%接受手术的胰腺癌患者的肿瘤复发。
四 | 它还可能增加其余80%至85%的晚期患者对标准化疗反应的持久性。
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